US and Israel launch major combat operations against Iran targeting nuclear facilities and military sites, with Trump calling for regime change and raising global concerns over escalating conflict in the Middle East.
The United States and Israel launched coordinated attacks on Iran early Saturday morning, with President Trump announcing 'major combat operations' targeting the country's nuclear facilities and military infrastructure. Explosions were reported in Tehran near Supreme Leader Ayatollah Ali Khamenei's offices, as well as in Isfahan, Qom, Karaj, Kermanshah, Kandahar, and Paktika. Israeli Defense Minister Israel Katz described the strikes as a 'pre-emptive attack' aimed at removing threats, while Trump stated the objective was 'to defend the American people by eliminating imminent threats from the Iranian regime.'
Trump's video address accused Iran of continuing to develop its nuclear program despite the destruction of facilities at Fordo, Natanz, and Isfahan during Operation Midnight Hammer last June. According to AP, the first apparent strike hit near Khamenei's compound in downtown Tehran, though it remains unclear whether the 86-year-old leader was present. Iran responded by launching missiles toward Israel and reportedly striking the US Navy 5th Fleet service center in Bahrain. Both Israel and Iran closed their airspace to civilian flights, with Israeli authorities warning citizens to shelter and avoid gatherings through Monday evening.
The operation follows months of escalating tensions after satellite imagery analyzed by AP showed new activity at two of Iran's previously bombed nuclear sites, suggesting attempts to assess or recover material. Trump appealed directly to the Iranian people in his address, urging them to 'take over your government' and calling it 'probably your only chance for generations.' Israeli Prime Minister Benjamin Netanyahu echoed this message, thanking Trump and calling on Iranians to 'throw off the yoke of tyranny.' Both leaders emphasized that Iran must not be allowed to develop nuclear weapons, with Trump warning of 'major civil and criminal consequences' if Iran doesn't comply with American demands.
Editor’s rationale — This is a major combat operation involving the US and Israel attacking Iran—a structural geopolitical and military event with immediate implications for Middle Eastern stability, regional security posture, and potential escalation of nuclear proliferation concerns. The story meets all highest thresholds: confirmed by the US President and Israeli PM, affects global markets and regional security, and carries multi-year strategic consequences.